Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2

The discoidin domain receptors, DDR1 and DDR2, are widely expressed receptor tyrosine kinases that are activated by triple-helical collagen. They control important aspects of cell behavior and are dysregulated in several human diseases. The major DDR2-binding site in collagens I–III is a GVMGFO moti...

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Bibliografiske detaljer
Main Authors: Carafoli, Federico, Bihan, Dominique, Stathopoulos, Stavros, Konitsiotis, Antonios D., Kvansakul, Marc, Farndale, Richard W., Leitinger, Birgit, Hohenester, Erhard
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807035/
https://ncbi.nlm.nih.gov/pubmed/20004161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.10.012
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