Proteinase-activated receptor-2 mediated inhibition of TNFα-stimulated JNK activation — A novel paradigm for G(q/11) linked GPCRs

In this study we examined the potential for PAR(2) and TNFα to synergise at the level of MAP kinase signalling in PAR(2) expressing NCTC2544 cells. However, to our surprise we found that activation of PAR(2) by trypsin or the specific activating peptide SLIGKV-OH strongly inhibited both the phosphor...

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Detaylı Bibliyografya
Asıl Yazarlar: McIntosh, Kathryn, Cunningham, Margaret R., Cadalbert, Laurence, Lockhart, John, Boyd, Gary, Ferrell, W.R., Plevin, Robin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier Science Ltd 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806525/
https://ncbi.nlm.nih.gov/pubmed/19781631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.09.028
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