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Proteinase-activated receptor-2 mediated inhibition of TNFα-stimulated JNK activation — A novel paradigm for G(q/11) linked GPCRs
In this study we examined the potential for PAR(2) and TNFα to synergise at the level of MAP kinase signalling in PAR(2) expressing NCTC2544 cells. However, to our surprise we found that activation of PAR(2) by trypsin or the specific activating peptide SLIGKV-OH strongly inhibited both the phosphor...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier Science Ltd
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806525/ https://ncbi.nlm.nih.gov/pubmed/19781631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.09.028 |
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