The development of proteinase-activated receptor-2 modulators and the challenges involved

Protease-activated receptor-2 (PAR2) has been extensively studied since its discovery in the mid-1990. Despite the advances in understanding PAR2 pharmacology, it has taken almost 25 years for the first inhibitor to reach clinical trials, and so far, no PAR2 antagonist has been approved for human us...

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發表在:Biochem Soc Trans
Main Authors: McIntosh, Kathryn A., Cunningham, Margaret R., Bushell, Trevor, Plevin, Robin
格式: Artigo
語言:Inglês
出版: Portland Press Ltd. 2020
主題:
Review Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7752072/
https://ncbi.nlm.nih.gov/pubmed/33242065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200191
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