The development of proteinase-activated receptor-2 modulators and the challenges involved

Protease-activated receptor-2 (PAR2) has been extensively studied since its discovery in the mid-1990. Despite the advances in understanding PAR2 pharmacology, it has taken almost 25 years for the first inhibitor to reach clinical trials, and so far, no PAR2 antagonist has been approved for human us...

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Bibliografiske detaljer
Udgivet i:Biochem Soc Trans
Main Authors: McIntosh, Kathryn A., Cunningham, Margaret R., Bushell, Trevor, Plevin, Robin
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2020
Fag:
Review Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7752072/
https://ncbi.nlm.nih.gov/pubmed/33242065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200191
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