The development of proteinase-activated receptor-2 modulators and the challenges involved

Protease-activated receptor-2 (PAR2) has been extensively studied since its discovery in the mid-1990. Despite the advances in understanding PAR2 pharmacology, it has taken almost 25 years for the first inhibitor to reach clinical trials, and so far, no PAR2 antagonist has been approved for human us...

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Vydáno v:Biochem Soc Trans
Hlavní autoři: McIntosh, Kathryn A., Cunningham, Margaret R., Bushell, Trevor, Plevin, Robin
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2020
Témata:
Review Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7752072/
https://ncbi.nlm.nih.gov/pubmed/33242065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200191
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