Proteinase-activated receptor-2 mediated inhibition of TNFα-stimulated JNK activation — A novel paradigm for G(q/11) linked GPCRs

In this study we examined the potential for PAR(2) and TNFα to synergise at the level of MAP kinase signalling in PAR(2) expressing NCTC2544 cells. However, to our surprise we found that activation of PAR(2) by trypsin or the specific activating peptide SLIGKV-OH strongly inhibited both the phosphor...

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Main Authors: McIntosh, Kathryn, Cunningham, Margaret R., Cadalbert, Laurence, Lockhart, John, Boyd, Gary, Ferrell, W.R., Plevin, Robin
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Science Ltd 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806525/
https://ncbi.nlm.nih.gov/pubmed/19781631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.09.028
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