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Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice

Defective lung septation and angiogenesis, quintessential features of neonatal chronic lung disease (CLD), typically result from lengthy exposure of developing lungs to mechanical ventilation (MV) and hyperoxia. Previous studies showed fewer alveoli and microvessels, with reduced VEGF and increased...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mokres, Lucia M., Parai, Kakoli, Hilgendorff, Anne, Ertsey, Robert, Alvira, Cristina M., Rabinovitch, Marlene, Bland, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806196/
https://ncbi.nlm.nih.gov/pubmed/19854954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00251.2009
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