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PKA, Rap1, ERK1/2, and p90RSK mediate PGE(2) and EP4 signaling in neonatal ventricular myocytes
We have previously reported that 1) inhibition of cyclooxygenase-2 and PGE(2) production reduces hypertrophy after myocardial infarction in mice and 2) PGE(2) acting through its EP4 receptor causes hypertrophy of neonatal ventricular myocytes (NVMs) via ERK1/2. It is known that EP4 couples to adenyl...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Physiological Society
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806144/ https://ncbi.nlm.nih.gov/pubmed/19880670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00251.2009 |
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