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Prostaglandin E(2) activates RAP1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: Involvement of EPAC1 and PKA: The regulation of Rap1 by PGE(2) in RSF

The small GTPase Rap1 is implicated in a variety of cellar functions. In this study, we investigated the effect of prostaglandin E(2) (PGE(2)) on Rap1 activation in rheumatoid synovial fibroblasts (RSF). Rap1 was expressed in RSF, and GTP-bound active Rap1 (GTP-Rap1) was rapidly increased by PGE(2)....

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Kojima, Fumiaki, Kapoor, Mohit, Kawai, Shinichi, Yang, Lihua, Aronoff, David M, Crofford, Leslie J
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	2009
الموضوعات:	Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2738595/ https://ncbi.nlm.nih.gov/pubmed/19464664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2009.03.001
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Prostaglandin E(2) activates RAP1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: Involvement of EPAC1 and PKA: The regulation of Rap1 by PGE(2) in RSF

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