Grape-Derived Polyphenolics Prevent Aβ Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) Aβ oligomers has been proposed to be largely responsible for AD dementia and memory deficits in the Tg2576...

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Bibliographic Details
Main Authors: Wang, Jun, Ho, Lap, Zhao, Wei, Ono, Kenjiro, Rosensweig, Clark, Chen, Linghong, Humala, Nelson, Teplow, David B., Pasinetti, Giulio M.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2008
Subjects:
Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806059/
https://ncbi.nlm.nih.gov/pubmed/18562609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0364-08.2008
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