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WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3

Werner syndrome (WS) is a premature aging disorder characterized by genomic instability. The WRN gene defective in WS encodes a protein with both helicase and exonuclease activities that interacts with proteins implicated in DNA metabolism. To understand its genetic functions, we examined the abilit...

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Détails bibliographiques
Auteurs principaux: Aggarwal, Monika, Brosh, Robert M.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806000/
https://ncbi.nlm.nih.gov/pubmed/20157511
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