AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations

Cancer initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID) produces widespread somatic mutation in mature B cells; however the extent of “off-target” DSB formation and its role...

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Detalhes bibliográficos
Main Authors: Robbiani, Davide F., Bunting, Samuel, Feldhahn, Niklas, Bothmer, Anne, Camps, Jordi, Deroubaix, Stephanie, McBride, Kevin M., Klein, Isaac A., Stone, Gary, Eisenreich, Thomas R., Ried, Thomas, Nussenzweig, André, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805907/
https://ncbi.nlm.nih.gov/pubmed/19941823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.11.007
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