AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations

Cancer initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID) produces widespread somatic mutation in mature B cells; however the extent of “off-target” DSB formation and its role...

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Autori principali: Robbiani, Davide F., Bunting, Samuel, Feldhahn, Niklas, Bothmer, Anne, Camps, Jordi, Deroubaix, Stephanie, McBride, Kevin M., Klein, Isaac A., Stone, Gary, Eisenreich, Thomas R., Ried, Thomas, Nussenzweig, André, Nussenzweig, Michel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805907/
https://ncbi.nlm.nih.gov/pubmed/19941823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.11.007
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