Regulation of G(1) Arrest and Apoptosis in Hypoxia by PERK and GCN2-Mediated eIF2α Phosphorylation

Hypoxia is a common microenvironment in solid tumors and is correlated with tumor progression by regulating cancer cell survival. Recent studies suggest that activation of double-stranded RNA-dependent protein kinase-like endoplasmic reticulum-related kinase (PERK) and phosphorylation of α subunit o...

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Bibliographic Details
Main Authors: Liu, Yan, László, Csaba, Liu, Yi, Liu, Wei, Chen, Xiaozhuo, Evans, Susan C, Wu, Shiyong
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805884/
https://ncbi.nlm.nih.gov/pubmed/20072654
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