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PERK and GCN2 Contribute to eIF2α Phosphorylation and Cell Cycle Arrest after Activation of the Unfolded Protein Response Pathway
Exposure of cells to endoplasmic reticulum (ER) stress leads to activation of PKR-like ER kinase (PERK), eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, repression of cyclin D1 translation, and subsequent cell cycle arrest in G(1) phase. However, whether PERK is solely responsib...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Cell Biology
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1289396/ https://ncbi.nlm.nih.gov/pubmed/16176978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-03-0268 |
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