PERK and GCN2 Contribute to eIF2α Phosphorylation and Cell Cycle Arrest after Activation of the Unfolded Protein Response Pathway

Exposure of cells to endoplasmic reticulum (ER) stress leads to activation of PKR-like ER kinase (PERK), eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, repression of cyclin D1 translation, and subsequent cell cycle arrest in G(1) phase. However, whether PERK is solely responsib...

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Bibliographic Details
Main Authors: Hamanaka, Robert B., Bennett, Beth S., Cullinan, Sara B., Diehl, J. Alan
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2005
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1289396/
https://ncbi.nlm.nih.gov/pubmed/16176978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-03-0268
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