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THE 1.4 Å CRYSTAL STRUCTURE OF THE CLASS D β-LACTAMASE OXA-1 COMPLEXED WITH DORIPENEM
The clinical efficacy of carbapenem antibiotics depends on their resistance to the hydrolytic action of β-lactamase enzymes. The structure of the class D β-lactamase OXA-1 as an acyl-complex with the carbapenem doripenem was determined to 1.4 Å resolution. Unlike most class A and class C carbapenem...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2805451/ https://ncbi.nlm.nih.gov/pubmed/19919101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901690r |
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