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Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury

Studies in experimental models and controlled patient trials indicate that opioids are effective in managing neuropathic pain. However, side effects secondary to their central nervous system actions present barriers to their clinical use. Therefore, we examined whether activation of the peripheral m...

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Bibliographic Details
Main Authors: Guan, Yun, Johanek, Lisa M., Hartke, Timothy V., Shim, Beom, Tao, Yuan-Xiang, Ringkamp, Matthias, Meyer, Richard A., Raja, Srinivasa N.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805197/
https://ncbi.nlm.nih.gov/pubmed/18276075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2008.01.004
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