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Over-expression of mu-opioid receptors in peripheral afferents, but not in combination with enkephalin, decreases neuropathic pain behavior and enhances opioid analgesia in mouse

BACKGROUND: The current study used recombinant herpes simplex virus type I to increase expression of mu opiate receptors and the opioid ligand preproenkephalin in peripheral nerve fibers in a mouse model of neuropathic pain. We predicted that viral vector delivery of a combination of genes encoding...

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書目詳細資料
發表在:Anesthesiology
Main Authors: Klein, Amanda H, Mohammad, Husam K, Ali, Rabiah, Peper, Brad, Wilson, Steven P, Raja, Srinivasa, Ringkamp, Matthias, Sweitzer, Sarah
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904001/
https://ncbi.nlm.nih.gov/pubmed/29334500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002063
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