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Over-expression of mu-opioid receptors in peripheral afferents, but not in combination with enkephalin, decreases neuropathic pain behavior and enhances opioid analgesia in mouse
BACKGROUND: The current study used recombinant herpes simplex virus type I to increase expression of mu opiate receptors and the opioid ligand preproenkephalin in peripheral nerve fibers in a mouse model of neuropathic pain. We predicted that viral vector delivery of a combination of genes encoding...
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| Publicado en: | Anesthesiology |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5904001/ https://ncbi.nlm.nih.gov/pubmed/29334500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002063 |
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