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STING an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signaling

We report here the identification, following expression cloning, of a molecule, STING (STimulator of INterferon Genes) that regulates innate immune signaling processes. STING, comprising 5 putative transmembrane (TM) regions, predominantly resides in the endoplasmic reticulum (ER) and is able to act...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ishikawa, Hiroki, Barber, Glen N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804933/
https://ncbi.nlm.nih.gov/pubmed/18724357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07317
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