Expression of the K303R Estrogen Receptor α Breast Cancer Mutation Induces Resistance to an Aromatase Inhibitor via Addiction to the PI3K/Akt Kinase Pathway

Aromatase inhibitors (AIs) are rapidly becoming the first choice for hormonal treatment of estrogen receptor alpha (ERα)-positive breast cancer in postmenopausal women. However, de novo and acquired resistance frequently occurs. We have previously identified a lysine to arginine transition at residu...

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Detalhes bibliográficos
Main Authors: Barone, Ines, Cui, Yukun, Herynk, Matthew H, Corona-Rodriguez, Arnoldo, Giordano, Cinzia, Selever, Jennifer, Beyer, Amanda, Andò, Sebastiano, Fuqua, Suzanne A. W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804866/
https://ncbi.nlm.nih.gov/pubmed/19487288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4194
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