Accelerated Mammary Maturation and Differentiation, and Delayed MMTV-Neu-Induced Tumorigenesis of K303R Mutant ERα Transgenic Mice

We identified a somatic mutation in ERα in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors, and altered posttranslational modifications of ERα. We have developed a transgenic mouse expres...

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Bibliographic Details
Published in:Oncogene
Main Authors: Herynk, MH, Lewis, MT, Hopp, TA, Medina, D, Corona-Rodriguez, A, Cui, Y, Beyer, AR, Fuqua, SAW
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484624/
https://ncbi.nlm.nih.gov/pubmed/19561644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.174
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