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N-terminal strands of filamin Ig domains act as a conformational switch under biological forces

Conformational changes of filamin A under stress have been postulated to play crucial roles in signaling pathways of cell responses. Direct observation of conformational changes under stress is beyond the resolution of current experimental techniques. On the other hand, computational studies are mai...

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Hlavní autoři: Kesner, Barry A., Ding, Feng, Temple, Brenda R., Dokholyan, Nikolay V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804786/
https://ncbi.nlm.nih.gov/pubmed/19514078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22479
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