Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

The carboxy-terminal domain (CTD) of the RNA polymerase II (Pol II) large subunit cycles through phosphorylation states that correlate with progression through the transcription cycle and regulate nascent mRNA processing. Structural analyses of yeast and mammalian CTD are hampered by their repetitiv...

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Publicado no:Nat Commun
Main Authors: Gibbs, Eric B., Lu, Feiyue, Portz, Bede, Fisher, Michael J., Medellin, Brenda P., Laremore, Tatiana N., Zhang, Yan Jessie, Gilmour, David S., Showalter, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437310/
https://ncbi.nlm.nih.gov/pubmed/28497798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15233
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