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Structural Characterization of the E2 Domain of APL-1, a Caenorhabditis elegans Homolog of Human Amyloid Precursor Protein, and Its Heparin Binding Site

The amyloid β-peptide deposit found in the brain tissue of patients with Alzheimer disease is derived from a large heparin-binding protein precursor APP. The biological function of APP and its homologs is not precisely known. Here we report the x-ray structure of the E2 domain of APL-1, an APP homol...

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書誌詳細
主要な著者: Hoopes, James T., Liu, Xuying, Xu, Xiaomeng, Demeler, Borries, Folta-Stogniew, Ewa, Li, Chris, Ha, Ya
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804372/
https://ncbi.nlm.nih.gov/pubmed/19906646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.018432
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