APL-1, a Caenorhabditis elegans protein related to the human β-amyloid precursor protein, is essential for viability

Dominant mutations in the amyloid precursor protein (APP) gene are associated with rare cases of familial Alzheimer's disease; however, the normal functions of APP and related proteins remain unclear. The nematode Caenorhabditis elegans has a single APP-related gene, apl-1, that is expressed in...

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Bibliographic Details
Main Authors: Hornsten, Angela, Lieberthal, Jason, Fadia, Shruti, Malins, Richard, Ha, Lawrence, Xu, Xiaomeng, Daigle, Isabelle, Markowitz, Mindy, O'Connor, Gregory, Plasterk, Ronald, Li, Chris
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794273/
https://ncbi.nlm.nih.gov/pubmed/17267616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603997104
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