Farnesyl Pyrophosphate Inhibits Epithelialization and Wound Healing through the Glucocorticoid Receptor

Farnesyl pyrophosphate (FPP), a key intermediate in the mevalonate pathway and protein farnesylation, can act as an agonist for several nuclear hormone receptors. Here we show a novel mechanism by which FPP inhibits wound healing acting as an agonist for glucocorticoid receptor (GR). Elevation of en...

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Main Authors: Vukelic, Sasa, Stojadinovic, Olivera, Pastar, Irena, Vouthounis, Constantinos, Krzyzanowska, Agata, Das, Sharmistha, Samuels, Herbert H., Tomic-Canic, Marjana
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804356/
https://ncbi.nlm.nih.gov/pubmed/19903814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016741
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