Up-regulation of Survivin by the E2A-HLF Chimera Is Indispensable for the Survival of t(17;19)-positive Leukemia Cells

The E2A-HLF fusion transcription factor generated by t(17;19)(q22;p13) translocation is found in a small subset of pro-B cell acute lymphoblastic leukemias (ALLs) and promotes leukemogenesis by substituting for the antiapoptotic function of cytokines. Here we show that t(17;19)(+) ALL cells express...

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Hauptverfasser: Okuya, Mayuko, Kurosawa, Hidemitsu, Kikuchi, Jiro, Furukawa, Yusuke, Matsui, Hirotaka, Aki, Daisuke, Matsunaga, Takayuki, Inukai, Takeshi, Goto, Hiroaki, Altura, Rachel A., Sugita, Kenich, Arisaka, Osamu, Look, A. Thomas, Inaba, Toshiya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Transcription, Chromatin, and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804343/
https://ncbi.nlm.nih.gov/pubmed/19887369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023762
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