Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting on O-Glucosylated Notch Epidermal Growth Factor Repeats

The epidermal growth factor repeats of the Notch receptor are extensively glycosylated with three different O-glycans. O-Fucosylation and elongation by the glycosyltransferase Fringe have been well studied and shown to be essential for proper Notch signaling. In contrast, biosynthesis of O-glucose a...

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Autori principali: Sethi, Maya K., Buettner, Falk F. R., Krylov, Vadim B., Takeuchi, Hideyuki, Nifantiev, Nikolay E., Haltiwanger, Robert S., Gerardy-Schahn, Rita, Bakker, Hans
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accelerated Publications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804315/
https://ncbi.nlm.nih.gov/pubmed/19940119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.065409
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