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A sweet development in Notch regulation
The transmembrane signaling protein Notch, which is crucial for embryonic cell fate decisions, has 36 extracellular EGF domains that are glycosylated in variable and complex ways. A new study shows that O-fucose and O-glucose stabilize the repeats but that extension of glucose by xylose weakens stab...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5612126/ https://ncbi.nlm.nih.gov/pubmed/28939751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.H117.800102 |
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