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Notch-modifying xylosyltransferase-substrate complexes support an S(N)i-like retaining mechanism
A major remaining question in glycobiology is how a glycosyltransferase (GT) that retains the anomeric linkage of a sugar catalyzes the reaction. Xylosideα1–3 Xylosyltransferase (XXYLT1) is a retaining GT that regulates Notch receptor activation by adding xylose to the Notch extracellular domain. He...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618232/ https://ncbi.nlm.nih.gov/pubmed/26414444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1927 |
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