O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking

Glycosylation in the endoplasmic reticulum (ER) is closely associated with protein folding and quality control. We recently described a non-canonical ER quality control mechanism for folding of thrombospondin type 1 repeats by protein O-fucosyltransferase 2 (POFUT2). Epidermal growth factor-like (EG...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Takeuchi, Hideyuki, Yu, Hongjun, Hao, Huilin, Takeuchi, Megumi, Ito, Atsuko, Li, Huilin, Haltiwanger, Robert S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612125/
https://ncbi.nlm.nih.gov/pubmed/28729422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.800102
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