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An Engineered Knottin Peptide Labeled with (18)F for PET Imaging of Integrin Expression

Knottins are small constrained polypeptides that share a common disulfide-bonded framework and a triple-stranded β-sheet fold. Previously, directed evolution of the Ecballium elaterium trypsin inhibitor (EETI-II) knottin led to the identification of a mutant that bound to tumor-specific α(v)β(3) and...

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Bibliografiska uppgifter
Huvudupphovsmän: Miao, Zheng, Ren, Gang, Liu, Hongguang, Kimura, Richard H., Jiang, Lei, Cochran, Jennifer R., Gambhir, Sanjiv Sam, Cheng, Zhen
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804269/
https://ncbi.nlm.nih.gov/pubmed/19908826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900361g
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