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An Engineered Knottin Peptide Labeled with (18)F for PET Imaging of Integrin Expression
Knottins are small constrained polypeptides that share a common disulfide-bonded framework and a triple-stranded β-sheet fold. Previously, directed evolution of the Ecballium elaterium trypsin inhibitor (EETI-II) knottin led to the identification of a mutant that bound to tumor-specific α(v)β(3) and...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804269/ https://ncbi.nlm.nih.gov/pubmed/19908826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900361g |
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