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Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death
Doxorubicin (DOX) is a potent anti-tumor drug known to cause heart failure. The transcription factor GATA4 antagonizes DOX-induced cardiotoxicity. However, the protective mechanism remains obscure. Autophagy is the primary cellular pathway for lysosomal degradation of long-lived proteins and organel...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804228/ https://ncbi.nlm.nih.gov/pubmed/19901028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070037 |
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