Hyperactive Intracellular Calcium Signaling Associated with Localized Mitochondrial Defects in Skeletal Muscle of an Animal Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by degeneration of motor neurons and atrophy of skeletal muscle. Mutations in the superoxide dismutase (SOD1) gene are linked to 20% cases of inherited ALS. Mitochondrial dysfunction has been implicated in the pathog...

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Bibliografiske detaljer
Main Authors: Zhou, Jingsong, Yi, Jianxun, Fu, Ronggen, Liu, Erdong, Siddique, Teepu, Ríos, Eduardo, Deng, Han-Xiang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804218/
https://ncbi.nlm.nih.gov/pubmed/19889637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041319
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