Adaptive Modifications in the Calpain/Calpastatin System in Brain Cells after Persistent Alteration in Ca(2+) Homeostasis

Persistent dysregulation in Ca(2+) homeostasis is a pervasive pathogenic mechanism in most neurodegenerative diseases, and accordingly, calpain activation has been implicated in neuronal cells dysfunction and death. In this study we examined the intracellular functional state of the calpain-calpasta...

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Autors principals: Stifanese, Roberto, Averna, Monica, De Tullio, Roberta, Pedrazzi, Marco, Beccaria, Francesco, Salamino, Franca, Milanese, Marco, Bonanno, Giambattista, Pontremoli, Sandro, Melloni, Edon
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804211/
https://ncbi.nlm.nih.gov/pubmed/19880516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.031674
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