Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol Metabolism

In the recently identified cholesterol catabolic pathway of Mycobacterium tuberculosis, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (HsaD) is proposed to catalyze the hydrolysis of a carbon-carbon bond in 4,5–9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic acid (DSHA), the c...

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Bibliographische Detailangaben
Hauptverfasser: Lack, Nathan A., Yam, Katherine C., Lowe, Edward D., Horsman, Geoff P., Owen, Robin L., Sim, Edith, Eltis, Lindsay D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804191/
https://ncbi.nlm.nih.gov/pubmed/19875455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.058081
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