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Calcium-activated Calpain-2 Is a Mediator of Beta Cell Dysfunction and Apoptosis in Type 2 Diabetes

The islet in type 2 diabetes (T2DM) and the brain in neurodegenerative diseases share progressive cell dysfunction, increased apoptosis, and accumulation of locally expressed amyloidogenic proteins (islet amyloid polypeptide (IAPP) in T2DM). Excessive activation of the Ca(2+)-sensitive protease calp...

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書誌詳細
主要な著者: Huang, Chang-jiang, Gurlo, Tatyana, Haataja, Leena, Costes, Safia, Daval, Marie, Ryazantsev, Sergey, Wu, Xiuji, Butler, Alexandra E., Butler, Peter C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804181/
https://ncbi.nlm.nih.gov/pubmed/19861418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024190
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