Calcium-activated Calpain-2 Is a Mediator of Beta Cell Dysfunction and Apoptosis in Type 2 Diabetes

The islet in type 2 diabetes (T2DM) and the brain in neurodegenerative diseases share progressive cell dysfunction, increased apoptosis, and accumulation of locally expressed amyloidogenic proteins (islet amyloid polypeptide (IAPP) in T2DM). Excessive activation of the Ca(2+)-sensitive protease calp...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Huang, Chang-jiang, Gurlo, Tatyana, Haataja, Leena, Costes, Safia, Daval, Marie, Ryazantsev, Sergey, Wu, Xiuji, Butler, Alexandra E., Butler, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804181/
https://ncbi.nlm.nih.gov/pubmed/19861418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024190
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados