Monoamine oxidase A mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload

RATIONALE: Monoamine oxidases (MAO) are mitochondrial enzymes that catabolize pro-hypertrophic neurotransmitters such as norepinephrine and serotonin, generating hydrogen peroxide. Since excess reactive oxygen species (ROS) and catecholamines are major contributors to the pathophysiology of congesti...

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Autori principali: Kaludercic, Nina, Takimoto, Eiki, Nagayama, Takahiro, Feng, Ning, Lai, Edwin W., Bedja, Djahida, Chen, Kevin, Gabrielson, Kathleen L, Blakely, Randy D, Shih, Jean C, Pacak, Karel, Kass, David A, Lisa, Fabio Di, Paolocci, Nazareno
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804073/
https://ncbi.nlm.nih.gov/pubmed/19910579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.198366
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