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Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of β-tubulin

The total synthesis of 22-(3-azidobenzoyloxy)methyl epothilone C is described as a potential photoaffinity probe to elucidate the β-tubulin binding site. A sequential Suzuki-aldol-Yamaguchi macrolactonization strategy was utilized employing a novel derivatized C1–C6 fragment. The C22-functionalized...

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Bibliografiske detaljer
Main Authors: Hutt, Oliver E., Inagaki, Jun, Reddy, Bollu S., Nair, Sajiv K., Reiff, Emily A., Henri, John T., Greiner, Jack F., VanderVelde, David G., Chiu, Ting-Lan, Amin, Elizabeth A., Himes, Richard H., Georg, Gunda I.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803616/
https://ncbi.nlm.nih.gov/pubmed/19428248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.04.077
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