Total Synthesis and Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin

Three photaffinity labeled derivatives of epothilone D were prepared by total synthesis, using efficient novel asymmetric synthesis methods for the preparation of two important synthetic building blocks. The key step for the asymmetric synthesis of (S,E)-3-(tert-butyldimethylsilyloxy)-4-methyl-5-(2-...

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Main Authors: Reiff, Emily A., Nair, Sajiv K., Henri, John T., Greiner, Jack F., Reddy, Bollu S., Chakrasali, Ramappa, David, Sunil A., Chiu, Ting-Lan, Amin, Elizabeth A., Himes, Richard H., Vander Velde, David G., Georg, Gunda I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798899/
https://ncbi.nlm.nih.gov/pubmed/19954175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo901752v
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