Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells.
Glucose is a well-known stimulus of proinsulin biosynthesis. In purified beta cells, the sugar induces a 25-fold increase in the synthesis of insulin immunoreactive material over 60-min incubation. Autoradiographic analysis of the individual cells shows that this effect is achieved via dose-dependen...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1988
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3287379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.11.3865 |
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