Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells.

Glucose is a well-known stimulus of proinsulin biosynthesis. In purified beta cells, the sugar induces a 25-fold increase in the synthesis of insulin immunoreactive material over 60-min incubation. Autoradiographic analysis of the individual cells shows that this effect is achieved via dose-dependen...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Schuit, F C, In't Veld, P A, Pipeleers, D G
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1988
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3287379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.11.3865
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