Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments

BACKGROUND: Progressive loss of articular cartilage is a central hallmark in many joint disease, however, the relative importance of individual proteolytic pathways leading to cartilage erosion is at present unknown. We therefore investigated the time-dependant release ex vivo of MMP- and aggrecanas...

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Autori principali: Wang, Bijue, Chen, Pingping, Jensen, Anne-Christine Bay, Karsdal, Morten A, Madsen, Suzi H, Sondergaard, Bodil-Cecilie, Zheng, Qinlong, Qvist, Per
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
Soggetti:
Short Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803187/
https://ncbi.nlm.nih.gov/pubmed/20021645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-2-259
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