p53 isoforms, Δ133p53 and p53β, are endogenous regulators of replicative cellular senescence

The finite proliferative potential of normal human cells leads to replicative cellular senescence, which is a critical barrier to tumour progression in vivo1–3. We show that human p53 isoforms (Δ133p53 and p53β)4 constitute an endogenous regulatory mechanism for p53-mediated replicative senescence....

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Bibliografiske detaljer
Main Authors: Fujita, Kaori, Mondal, Abdul M., Horikawa, Izumi, Nguyen, Giang H., Kumamoto, Kensuke, Sohn, Jane J., Bowman, Elise D., Mathe, Ewy A., Schetter, Aaron J., Pine, Sharon R., Ji, Helen, Vojtesek, Borivoj, Bourdon, Jean-Christophe, Lane, David P., Harris, Curtis C.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802853/
https://ncbi.nlm.nih.gov/pubmed/19701195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1928
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