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Molecular cloning of L-methylmalonyl-CoA mutase: gene transfer and analysis of mut cell lines.
L-Methylmalonyl-CoA mutase (MCM, EC 5.4.99.2) is a mitochondrial adenosylcobalamin-requiring enzyme that catalyzes the isomerization of L-methylmalonyl-CoA to succinyl-CoA. This enzyme is deficient in methylmalonic acidemia, an often fatal disorder of organic acid metabolism. Antibody against human...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1988
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280243/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2453061/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3518 |
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