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Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington’s Disease
Huntington’s disease (HD) is a neurodegenerative disorder caused by a polyglutamine repeat expansion in huntingtin. A newly developed BAC transgenic mouse model (BACHD) reproduces phenotypic features of HD including predominantly neuropil associated protein aggregation and progressive motor dysfunct...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802129/ https://ncbi.nlm.nih.gov/pubmed/18854207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2008.09.020 |
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