Progressive Cognitive Deficit, Motor Impairment and Striatal Pathology in a Transgenic Huntington Disease Monkey Model from Infancy to Adulthood

One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses cognitive and motor assessment, and neuroimaging of...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chan, Anthony W. S., Jiang, Jie, Chen, Yiju, Li, Chunxia, Prucha, Melinda S., Hu, Yijuan, Chi, Tim, Moran, Sean, Rahim, Tayeb, Li, Shihua, Li, Xiaojiang, Zola, Stuart M., Testa, Claudia M., Mao, Hui, Villalba, Rosa, Smith, Yoland, Zhang, Xiaodong, Bachevalier, Jocelyne
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428630/
https://ncbi.nlm.nih.gov/pubmed/25966278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122335
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