Progressive Cognitive Deficit, Motor Impairment and Striatal Pathology in a Transgenic Huntington Disease Monkey Model from Infancy to Adulthood

One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses cognitive and motor assessment, and neuroimaging of...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Chan, Anthony W. S., Jiang, Jie, Chen, Yiju, Li, Chunxia, Prucha, Melinda S., Hu, Yijuan, Chi, Tim, Moran, Sean, Rahim, Tayeb, Li, Shihua, Li, Xiaojiang, Zola, Stuart M., Testa, Claudia M., Mao, Hui, Villalba, Rosa, Smith, Yoland, Zhang, Xiaodong, Bachevalier, Jocelyne
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428630/
https://ncbi.nlm.nih.gov/pubmed/25966278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122335
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