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Poly(A) signal-dependent degradation of unprocessed nascent transcripts accompanies poly(A) signal-dependent transcriptional pausing in vitro

The poly(A) signal has long been known for its role in directing the cleavage and polyadenylation of eukaryotic mRNA. In recent years its additional coordinating role in multiple related aspects of gene expression has also become increasingly clear. Here we use HeLa nuclear extracts to study two of...

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Bibliografiske detaljer
Main Authors: Kazerouninia, Amir, Ngo, Benson, Martinson, Harold G.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802029/
https://ncbi.nlm.nih.gov/pubmed/19926725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1622010
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