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In vivo genetic evidence for suppressing vascular and soft tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin-D levels

BACKGROUND: Klotho knockout mice (klotho(-/-)) have increased renal expression of sodium/phosphate co-transporters (NaPi2a), associated with severe hyperphosphatemia. Such serum biochemical changes in klotho(-/-)mice lead to extensive soft tissue anomalies and vascular calcification. To determine th...

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書誌詳細
主要な著者: Ohnishi, Mutsuko, Nakatani, Teruyo, Lanske, Beate, Razzaque, M. Shawkat
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801877/
https://ncbi.nlm.nih.gov/pubmed/20031638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.108.847814
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