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In vivo genetic evidence for suppressing vascular and soft tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin-D levels
BACKGROUND: Klotho knockout mice (klotho(-/-)) have increased renal expression of sodium/phosphate co-transporters (NaPi2a), associated with severe hyperphosphatemia. Such serum biochemical changes in klotho(-/-)mice lead to extensive soft tissue anomalies and vascular calcification. To determine th...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801877/ https://ncbi.nlm.nih.gov/pubmed/20031638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.108.847814 |
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